ECCO has four issues of this serial. It covers the law courts' and universities' terms, the influence of astrology over dates and parts of the body (with an illustration showing Man's Body which is clearly female), the phases of the moon, calendar of the church, and weather forecasts (in June 1658 cold and dark weather with showers of rain will give way to a wholsome air with some gentle showres). Jinner added new features from time to time. From 1659 she appended an address To the Reader. The first of these expresses regret that people are often too embarrassed to be clear when consulting a doctor about sexual problems. She recommends further reading matter about health and fertility (and how to conceive either a boy or a girl); she desires that our Sex may be furnished with knowledge: if they knew better, they would do better. In 1660 this address refers darkly to political events both past and to come; this year Jinner's expanded almanac lists the dates of monarchs' reigns since the Norman Conquest, and adds recipes for medicines of all kinds, and detailed prognostications for each month, not only on agricultural matters but for instance, for April, a probability of revolution for princes and states, with public affairs ill-joynted and discomposed. Jinner adds wryly: I know not what this Moneth is good for else, than to marry in it: the Woman will be fruitful, and the Man more constant than ordinary. She then says that July will be worse, with miscarriages, deaths in childbed, smallpox, and suicides.

Newspapers reported the royal plan for an experiment as to the safety of inoculation against smallpox, to be conducted on inmates of Newgate Prison in London.

The nineteenth century also saw epidemics of yellow fever, smallpox, diptheria, scarlet fever, dysentery, typhus and typhoid. Tuberculosis was ever-present.

It was not aimed at smallpox (though that was in the headlines) but at the plague, which was much feared as an import from Europe.

The Vaccination Act or (Act to Extend the Practice of Vaccination) was the first of a series of such acts passed in response to an epidemic of smallpox among the poor between 1837 and 1840.

London, with a population estimated at three quarters of a million and after fifty years of inoculation in England, recorded well over a thousand deaths from smallpox. This was less than the previous major epidemic twenty-one years before, but still considered average.

The Public Health Act (Scotland) provided for the setting up of isolation hospitals: local smallpox was eradicated in seven years from this Act, after 34 years of compulsory vaccination had failed.

Carolan was born in 1670, and blinded by smallpox at the age of eighteen. His musical style blends the baroque (modern) with the ancient. Mary Delany was one of his patrons.

The ghost (supposed to be that of a young woman who had recently died while pregnant) appeared to a girl in whose family home the woman had lodged while living, to accuse her lover of her murder. The lover claimed that he had been devoted to her (they would have been married but for the prohibition on marrying a deceased wife's sister) and that she died of smallpox. But the allegation investigated was that of a ghost, not that of a murder.

William Duke of Gloucester , born in 1689, longest-surviving child of the future Queen Anne , died of smallpox.

The Vaccination Act made vaccination against smallpox compulsory for everyone in the United Kingdom, and provided for administering it gratis under the Poor Law.

An international effort to defeat disease, suggested by the success of smallpox vaccination, began at a conference in Paris this year.

Massey argued that smallpox, like other troubles, was sent by God either to test or to punish. Therefore, inoculation would be trespassing on God's prerogative; the first inoculator was Satan when he struck Job with boils.

A combined French and Spanish fleet, massed in the English Channel for invasion of southern England, retired in disarray after smallpox broke out on one of the ships and spread rapidly.

Louis XV of France, great-grandson and immediate successor of the Sun King , died of smallpox, and was succeeded by his grandson Louis XVI .

The Royal College of Physicians made public their official approval of inoculation for smallpox, as introduced to England by Lady Mary Wortley Montagu thirty-three years before.

All children were required to be vaccinated against smallpox, notwithstanding well-founded doubts about the safety and efficacy of the procedure. Noncomplying parents could be fined, have their household goods distrained or sold, or be jailed. Despite the growing anti-vaccination movement, provisions for conscientious objectors were not available until 1898.

General Jeffrey Amherst , British commander in North America, suggested that smallpox might advantageously be introduced among the disaffected tribes of Indians currently being led in rebellion by Pontiac .